Dapoxetine, marketed as Priligy, among others, is a medication used for the treatment of premature ejaculation in men 18–64 years old. Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin’s action at the postsynaptic cleft, and as a consequence promoting ejaculatory delay.
Premature ejaculation (PE) is when ejaculation happens sooner than a man or his partner would like during sex. PE is also known as rapid ejaculation, premature climax or early ejaculation. PE might not be a cause for worry. It can be frustrating if it makes sex less enjoyable and impacts relationships.
Erectile dysfunction can be a sign of a physical or psychological condition. It can cause stress, relationship strain and low self-confidence.
The main symptom is a man’s inability to get or keep an erection firm enough for sexual intercourse.
Patients suffering from erectile dysfunction should first be evaluated for any underlying physical and psychological conditions. If treatment of the underlying conditions doesn’t help, medication and assistive devices, such as pumps, can be prescribed.
The four major PDE5 inhibitors are sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra), and avanafil (Stendra). During the penile erection process, cGMP is metabolized through the PDE5 enzyme and cannot exert its downstream erectile effects
If you have been in a situation where you could not achieve and maintain an erection when you expected to, you know the emotional whirlwind